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UniProt functional annotation for Q12567 | ||
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| UniProt code: Q12567. |
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| Organism: | |
Aspergillus phoenicis (Aspergillus saitoi). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus. |
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| Function: | |
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A. {ECO:0000269|PubMed:13702766, ECO:0000269|PubMed:21699, ECO:0000269|Ref.4}. |
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| Catalytic activity: | |
Reaction=Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.; EC=3.4.23.18; Evidence={ECO:0000269|PubMed:21699}; |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 2.9-3.3. {ECO:0000269|Ref.4}; |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:5886141}. |
| Subcellular location: | |
Secreted {ECO:0000269|Ref.4}. |
| Similarity: | |
Belongs to the peptidase A1 family. {ECO:0000255|PROSITE- ProRule:PRU01103}. |
Annotations taken from UniProtKB at the EBI.