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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Cell adhesion
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Title:
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Beta-catenin/phosphorylated e-cadherin complex
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Structure:
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Beta-catenin. Chain: a, c. Fragment: armadillo domain. Engineered: yes. Epithelial-cadherin. Chain: b, d. Fragment: cytoplasmic domain. Synonym: e-cadherin. Engineered: yes
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Source:
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Mus musculus. House mouse. Organism_taxid: 10090. Gene: catnb. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cdh1. Expression_system_taxid: 562
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Biol. unit:
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Tetramer (from
)
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Resolution:
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2.00Å
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R-factor:
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0.206
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R-free:
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0.245
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Authors:
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A.H.Huber,W.I.Weis
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Key ref:
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A.H.Huber
and
W.I.Weis
(2001).
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.
Cell,
105,
391-402.
PubMed id:
DOI:
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Date:
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10-Mar-01
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Release date:
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09-May-01
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PROCHECK
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Headers
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References
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Q02248
(CTNB1_MOUSE) -
Catenin beta-1 from Mus musculus
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Seq:
Struc:
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781 a.a.
500 a.a.
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DOI no:
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Cell
105:391-402
(2001)
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PubMed id:
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The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.
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A.H.Huber,
W.I.Weis.
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ABSTRACT
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As a component of adherens junctions and the Wnt signaling pathway, beta-catenin
binds cadherins, Tcf family transcription factors, and the tumor suppressor APC.
We have determined the crystal structures of both unphosphorylated and
phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat
region of beta-catenin. The interaction spans all 12 arm repeats, and features
quasi-independent binding regions that include helices which interact with both
ends of the arm repeat domain and an extended stretch of 14 residues which
closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in
interactions with a hydrophobic patch of beta-catenin that mimics the binding of
an amphipathic XTcf-3 helix. APC contains sequences homologous to the
phosphorylated region of cadherin, and is likely to bind similarly.
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Selected figure(s)
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Figure 2.
Figure 2. Interaction Regions I and IIβ-catenin is
represented as in Figure 1, and the arm repeats are marked
“R.” Residues of β-catenin are labeled in bold italics, and
residues of E-cadherin in plain text. Oxygen, nitrogen, and
sulfur are shown as red, blue, and green spheres, respectively.
Individual side chains of β-catenin are shown in purple (H3) or
gray (others). In this and Figures 3, 5, and 6, only those
β-catenin residues that form direct contacts with E-cadherin
are shown. E-cadherin is shown with yellow bonds. Hydrogen bonds
and salt bridges are shown as thin pink lines. (A) Region I.
Nearby region III residues are shown in light yellow. (B) Region
II
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Figure 6.
Figure 6. Comparison of E[cyto] and XTcf-3 Binding to
β-CateninE-cadherin is shown in yellow and XTcf-3 in green. (A)
Overall comparison of E-cadherin and XTcf-3 bound to β-catenin.
(B) Overlay of the extended region III of E-cadherin with the
corresponding portion of XTcf-3. (C) Comparison of the
phosphorylated region IV interaction. Figure colored as in
Figure 2 and Figure 4
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The above figures are
reprinted
by permission from Cell Press:
Cell
(2001,
105,
391-402)
copyright 2001.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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| |
PubMed id
|
|
Reference
|
|
|
|
|
|
A.Al-Amoudi,
D.Castaño-Diez,
D.P.Devos,
R.B.Russell,
G.T.Johnson,
and
A.S.Frangakis
(2011).
The three-dimensional molecular structure of the desmosomal plaque.
|
| |
Proc Natl Acad Sci U S A,
108,
6480-6485.
|
|
|
|
|
|
|
D.J.Dickinson,
W.J.Nelson,
and
W.I.Weis
(2011).
A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins.
|
| |
Science,
331,
1336-1339.
|
|
|
|
|
|
|
F.C.Gonsalves,
K.Klein,
B.B.Carson,
S.Katz,
L.A.Ekas,
S.Evans,
R.Nagourney,
T.Cardozo,
A.M.Brown,
and
R.DasGupta
(2011).
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.
|
| |
Proc Natl Acad Sci U S A,
108,
5954-5963.
|
|
|
|
|
|
|
G.Drechsel,
J.Bergler,
K.Wippel,
N.Sauer,
K.Vogelmann,
and
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(2011).
C-terminal armadillo repeats are essential and sufficient for association of the plant U-box armadillo E3 ubiquitin ligase SAUL1 with the plasma membrane.
|
| |
J Exp Bot,
62,
775-785.
|
|
|
|
|
|
|
H.K.Ha,
H.J.Park,
and
N.C.Park
(2011).
Expression of E-cadherin and α-catenin in a varicocele-induced infertility rat model.
|
| |
Asian J Androl,
13,
470-475.
|
|
|
|
|
|
|
J.Brasch,
O.J.Harrison,
G.Ahlsen,
S.M.Carnally,
R.M.Henderson,
B.Honig,
and
L.Shapiro
(2011).
Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.
|
| |
J Mol Biol,
408,
57-73.
|
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PDB code:
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S.Mokhtarzada,
C.Yu,
A.Brickenden,
and
W.Y.Choy
(2011).
Structural characterization of partially disordered human chibby: insights into its function in the wnt-signaling pathway.
|
| |
Biochemistry,
50,
715-726.
|
|
|
|
|
|
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W.Wang,
H.Liu,
S.Wang,
X.Hao,
and
L.Li
(2011).
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis.
|
| |
Cell Res,
21,
730-740.
|
|
|
|
|
|
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C.H.Lee,
H.W.Hung,
P.H.Hung,
and
Y.S.Shieh
(2010).
Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.
|
| |
Mol Cancer,
9,
64.
|
|
|
|
|
|
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E.Papusheva,
and
C.P.Heisenberg
(2010).
Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis.
|
| |
EMBO J,
29,
2753-2768.
|
|
|
|
|
|
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H.Armanious,
P.Gelebart,
J.Mackey,
Y.Ma,
and
R.Lai
(2010).
STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer.
|
| |
Int J Clin Exp Pathol,
3,
654-664.
|
|
|
|
|
|
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J.Heuberger,
and
W.Birchmeier
(2010).
Interplay of cadherin-mediated cell adhesion and canonical wnt signaling.
|
| |
Cold Spring Harb Perspect Biol,
2,
a002915.
|
|
|
|
|
|
|
M.T.Maher,
R.Mo,
A.S.Flozak,
O.N.Peled,
and
C.J.Gottardi
(2010).
Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling.
|
| |
PLoS One,
5,
e10184.
|
|
|
|
|
|
|
N.Ishiyama,
S.H.Lee,
S.Liu,
G.Y.Li,
M.J.Smith,
L.F.Reichardt,
and
M.Ikura
(2010).
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.
|
| |
Cell,
141,
117-128.
|
|
|
PDB codes:
|
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|
|
|
|
|
|
N.Jiménez-Menéndez,
P.Fernández-Millán,
A.Rubio-Cosials,
C.Arnan,
J.Montoya,
H.T.Jacobs,
P.Bernadó,
M.Coll,
I.Usón,
and
M.Solà
(2010).
Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.
|
| |
Nat Struct Mol Biol,
17,
891-893.
|
|
|
PDB codes:
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|
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T.M.Gloster,
and
D.J.Vocadlo
(2010).
Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes.
|
| |
Curr Signal Transduct Ther,
5,
74-91.
|
|
|
|
|
|
|
Y.Komarova,
and
A.B.Malik
(2010).
Regulation of endothelial permeability via paracellular and transcellular transport pathways.
|
| |
Annu Rev Physiol,
72,
463-493.
|
|
|
|
|
|
|
Y.S.Kim,
D.H.Shin,
J.S.Choi,
and
K.H.Kim
(2010).
The Immunohistochemical Patterns of the beta-Catenin Expression in Pilomatricoma.
|
| |
Ann Dermatol,
22,
284-289.
|
|
|
|
|
|
|
B.Mészáros,
I.Simon,
and
Z.Dosztányi
(2009).
Prediction of protein binding regions in disordered proteins.
|
| |
PLoS Comput Biol,
5,
e1000376.
|
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|
|
B.Mínguez,
V.Tovar,
D.Chiang,
A.Villanueva,
and
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(2009).
Pathogenesis of hepatocellular carcinoma and molecular therapies.
|
| |
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25,
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|
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|
|
|
|
|
C.Medrek,
G.Landberg,
T.Andersson,
and
K.Leandersson
(2009).
Wnt-5a-CKI{alpha} Signaling Promotes {beta}-Catenin/E-Cadherin Complex Formation and Intercellular Adhesion in Human Breast Epithelial Cells.
|
| |
J Biol Chem,
284,
10968-10979.
|
|
|
|
|
|
|
C.Mosimann,
G.Hausmann,
and
K.Basler
(2009).
Beta-catenin hits chromatin: regulation of Wnt target gene activation.
|
| |
Nat Rev Mol Cell Biol,
10,
276-286.
|
|
|
|
|
|
|
H.J.Choi,
J.C.Gross,
S.Pokutta,
and
W.I.Weis
(2009).
Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.
|
| |
J Biol Chem,
284,
31776-31788.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Wu,
K.Symes,
D.C.Seldin,
and
I.Dominguez
(2009).
Threonine 393 of beta-catenin regulates interaction with Axin.
|
| |
J Cell Biochem,
108,
52-63.
|
|
|
|
|
|
|
L.Shapiro,
and
W.I.Weis
(2009).
Structure and biochemistry of cadherins and catenins.
|
| |
Cold Spring Harbor Perspect Biol,
1,
a003053.
|
|
|
|
|
|
|
P.D.McCrea,
D.Gu,
and
M.S.Balda
(2009).
Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene Activity.
|
| |
Cold Spring Harbor Perspect Biol,
1,
a002923.
|
|
|
|
|
|
|
R.Mo,
T.L.Chew,
M.T.Maher,
G.Bellipanni,
E.S.Weinberg,
and
C.J.Gottardi
(2009).
The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex.
|
| |
J Biol Chem,
284,
28222-28231.
|
|
|
|
|
|
|
S.L.Lai,
A.J.Chien,
and
R.T.Moon
(2009).
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.
|
| |
Cell Res,
19,
532-545.
|
|
|
|
|
|
|
Y.An,
C.Y.Chen,
B.Moyer,
P.Rotkiewicz,
M.A.Elsliger,
A.Godzik,
I.A.Wilson,
and
W.E.Balch
(2009).
Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering.
|
| |
J Mol Biol,
391,
26-41.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Mao,
B.Kucuk,
and
K.D.Irvine
(2009).
Drosophila lowfat, a novel modulator of Fat signaling.
|
| |
Development,
136,
3223-3233.
|
|
|
|
|
|
|
A.Hartsock,
and
W.J.Nelson
(2008).
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.
|
| |
Biochim Biophys Acta,
1778,
660-669.
|
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|
|
A.Klaus,
and
W.Birchmeier
(2008).
Wnt signalling and its impact on development and cancer.
|
| |
Nat Rev Cancer,
8,
387-398.
|
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|
|
A.Taddei,
C.Giampietro,
A.Conti,
F.Orsenigo,
F.Breviario,
V.Pirazzoli,
M.Potente,
C.Daly,
S.Dimmeler,
and
E.Dejana
(2008).
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
|
| |
Nat Cell Biol,
10,
923-934.
|
|
|
|
|
|
|
C.J.Gottardi,
and
M.Peifer
(2008).
Terminal regions of beta-catenin come into view.
|
| |
Structure,
16,
336-338.
|
|
|
|
|
|
|
D.Acehan,
C.Petzold,
I.Gumper,
D.D.Sabatini,
E.J.Müller,
P.Cowin,
and
D.L.Stokes
(2008).
Plakoglobin is required for effective intermediate filament anchorage to desmosomes.
|
| |
J Invest Dermatol,
128,
2665-2675.
|
|
|
|
|
|
|
I.M.Somorjai,
and
A.Martinez-Arias
(2008).
Wingless signalling alters the levels, subcellular distribution and dynamics of Armadillo and E-cadherin in third instar larval wing imaginal discs.
|
| |
PLoS ONE,
3,
e2893.
|
|
|
|
|
|
|
J.Kitchen,
R.E.Saunders,
and
J.Warwicker
(2008).
Charge environments around phosphorylation sites in proteins.
|
| |
BMC Struct Biol,
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|
|
|
|
|
|
|
J.Liu,
B.T.Phillips,
M.F.Amaya,
J.Kimble,
and
W.Xu
(2008).
The C. elegans SYS-1 protein is a bona fide beta-catenin.
|
| |
Dev Cell,
14,
751-761.
|
|
|
PDB codes:
|
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|
|
|
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|
|
L.Jin,
Y.Li,
C.J.Chen,
M.A.Sherman,
K.Le,
and
J.E.Shively
(2008).
Direct interaction of tumor suppressor CEACAM1 with beta catenin: identification of key residues in the long cytoplasmic domain.
|
| |
Exp Biol Med (Maywood),
233,
849-859.
|
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|
|
|
|
M.P.Stemmler
(2008).
Cadherins in development and cancer.
|
| |
Mol Biosyst,
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|
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|
|
M.W.Curtis,
K.R.Johnson,
and
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(2008).
E-cadherin/catenin complexes are formed cotranslationally in the endoplasmic reticulum/Golgi compartments.
|
| |
Cell Commun Adhes,
15,
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|
|
|
|
|
|
|
O.Sokolova,
P.M.Bozko,
and
M.Naumann
(2008).
Helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity.
|
| |
J Biol Chem,
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|
|
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|
|
R.Götz
(2008).
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression.
|
| |
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|
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|
R.L.Nachman,
and
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(2008).
Platelets, petechiae, and preservation of the vascular wall.
|
| |
N Engl J Med,
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|
S.Bahmanyar,
D.D.Kaplan,
J.G.Deluca,
T.H.Giddings,
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M.Winey,
E.D.Salmon,
P.J.Casey,
W.J.Nelson,
and
A.I.Barth
(2008).
beta-Catenin is a Nek2 substrate involved in centrosome separation.
|
| |
Genes Dev,
22,
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|
|
|
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|
|
S.E.Grosskurth,
D.Bhattacharya,
Q.Wang,
and
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(2008).
Emergence of Xin demarcates a key innovation in heart evolution.
|
| |
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|
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E.M.Ullian,
and
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(2008).
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|
| |
J Cell Biol,
183,
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|
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|
|
|
|
|
T.Nakamura,
T.Hayashi,
Y.Nasu-Nishimura,
F.Sakaue,
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and
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(2008).
PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.
|
| |
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22,
1244-1256.
|
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T.L.Clemens,
and
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(2008).
Smad7 Stabilizes {beta}-Catenin Binding to E-cadherin Complex and Promotes Cell-Cell Adhesion.
|
| |
J Biol Chem,
283,
23956-23963.
|
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|
C.T.Capaldo,
and
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(2007).
Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells.
|
| |
Mol Biol Cell,
18,
189-200.
|
|
|
|
|
|
|
D.L.Stokes
(2007).
Desmosomes from a structural perspective.
|
| |
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565-571.
|
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E.Hofer,
and
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(2007).
Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis.
|
| |
Thromb Haemost,
97,
355-363.
|
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|
J.Rhee,
T.Buchan,
L.Zukerberg,
J.Lilien,
and
J.Balsamo
(2007).
Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription.
|
| |
Nat Cell Biol,
9,
883-892.
|
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|
K.Kizhatil,
J.Q.Davis,
L.Davis,
J.Hoffman,
B.L.Hogan,
and
V.Bennett
(2007).
Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.
|
| |
J Biol Chem,
282,
26552-26561.
|
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|
M.Perrais,
X.Chen,
M.Perez-Moreno,
and
B.M.Gumbiner
(2007).
E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions.
|
| |
Mol Biol Cell,
18,
2013-2025.
|
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|
M.Ritco-Vonsovici,
A.Ababou,
and
M.Horton
(2007).
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|
| |
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|
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N.Gavert,
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(2007).
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|
| |
J Cell Biochem,
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|
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|
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PDB code:
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..Dahle,
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PDB code:
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The cytoplasmic face of cell contact sites.
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PDB codes:
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PDB code:
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|
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PDB code:
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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