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UniProt functional annotation for P34071 | ||
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| UniProt code: P34071. |
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| Organism: | |
Staphylococcus aureus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines (PubMed:2210803, PubMed:19246739, PubMed:14559915). Causes also the intoxication staphylococcal food poisoning syndrome (PubMed:19246739). {ECO:0000269|PubMed:14559915, ECO:0000269|PubMed:19246739, ECO:0000269|PubMed:2210803}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Possesses two zinc-binding sites. The zinc ion is necessary for the toxin interaction with MHC class II. {ECO:0000269|PubMed:14559915}; |
| Subunit: | |
Interacts with host MHC class II molecules composed of alpha/HLA-DRA and beta/HLA-DRB1 chains. {ECO:0000269|PubMed:2210803}. |
| Subcellular location: | |
Secreted. |
| Similarity: | |
Belongs to the staphylococcal/streptococcal toxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.