|
|
||
|
|
|
|
|
UniProt functional annotation for Q12650 | ||
|
|
|
|
|
|
||
| UniProt code: Q12650. |
|
||
| Organism: | |
Penicillium chrysogenum (Penicillium notatum). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium; Penicillium chrysogenum species complex. |
|
||
|
||
| Function: | |
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. {ECO:0000255|HAMAP-Rule:MF_03106}. |
|
||
| Catalytic activity: | |
Reaction=ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate; Xref=Rhea:RHEA:18133, ChEBI:CHEBI:15378, ChEBI:CHEBI:16189, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58243; EC=2.7.7.4; Evidence={ECO:0000255|HAMAP- Rule:MF_03106}; |
| Activity regulation: | |
Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS). {ECO:0000255|HAMAP-Rule:MF_03106}. |
| Pathway: | |
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. {ECO:0000255|HAMAP-Rule:MF_03106}. |
| Subunit: | |
Homohexamer. Dimer of trimers. {ECO:0000255|HAMAP- Rule:MF_03106, ECO:0000269|PubMed:11389593, ECO:0000269|PubMed:12426581}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03106}. |
| Domain: | |
The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme. {ECO:0000255|HAMAP-Rule:MF_03106}. |
| Similarity: | |
In the N-terminal section; belongs to the sulfate adenylyltransferase family. {ECO:0000255|HAMAP-Rule:MF_03106}. |
| Similarity: | |
In the C-terminal section; belongs to the APS kinase family. {ECO:0000255|HAMAP-Rule:MF_03106}. |
Annotations taken from UniProtKB at the EBI.