|
|
||
|
|
|
|
|
UniProt functional annotation for Q15075 | ||
|
|
|
|
|
|
||
| UniProt code: Q15075. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
|
||
| Subunit: | |
Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. Interacts with SAMD9 AND SAMD9L (PubMed:24029230). May interact with PLEKHF2. {ECO:0000269|PubMed:10394369, ECO:0000269|PubMed:10491193, ECO:0000269|PubMed:10506127, ECO:0000269|PubMed:10807926, ECO:0000269|PubMed:11230696, ECO:0000269|PubMed:11741531, ECO:0000269|PubMed:11870209, ECO:0000269|PubMed:12493736, ECO:0000269|PubMed:16314522, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:22816767, ECO:0000269|PubMed:24029230, ECO:0000269|PubMed:9697774}. |
| Subcellular location: | |
Cytoplasm. Early endosome membrane; Peripheral membrane protein. |
| Domain: | |
The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. {ECO:0000269|PubMed:19296456}. |
| Miscellaneous: | |
Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. |
Annotations taken from UniProtKB at the EBI.