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PDBsum entry 1htm
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Viral protein
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PDB id
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1htm
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Structure of influenza haemagglutinin at the ph of membrane fusion.
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Authors
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P.A.Bullough,
F.M.Hughson,
J.J.Skehel,
D.C.Wiley.
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Ref.
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Nature, 1994,
371,
37-43.
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PubMed id
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Abstract
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Low pH induces a conformational change in the influenza virus haemagglutinin,
which then mediates fusion of the viral and host cell membranes. The
three-dimensional structure of a fragment of the haemagglutinin in this
conformation reveals a major refolding of the secondary and tertiary structure
of the molecule. The apolar fusion peptide moves at least 100 A to one tip of
the molecule. At the other end a helical segment unfolds, a subdomain relocates
reversing the chain direction, and part of the structure becomes disordered.
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Secondary reference #1
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Title
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Crystals of a fragment of influenza haemagglutinin in the low ph induced conformation.
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Authors
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P.A.Bullough,
F.M.Hughson,
A.C.Treharne,
R.W.Ruigrok,
J.J.Skehel,
D.C.Wiley.
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Ref.
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J Mol Biol, 1994,
236,
1262-1265.
[DOI no: ]
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PubMed id
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Figure 2.
Figure 2. Paterson prjection calculated from type IV
crvstal t 5 A esolution. The projection s own M and 1
unit, cell is shown. Contours are drawn at intervals corre-
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Figure 3.
Figure 3. Sections of he Patterson map calculated for
the type V crystal at A resolution and skewed to view
down the non-crystallographic 3-fold symmetry axis.
Sections at a perpendicular distance of approximately 2, 3
and A from he rigin are verlaid. Contours are as for
Figure tarting at 2 x .m.s. density above mean. The
length of he U' axis s 1 I6 A.
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The above figures are
reproduced from the cited reference
with permission from Elsevier
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Secondary reference #2
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Title
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Refinement of the influenza virus hemagglutinin by simulated annealing.
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Authors
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W.I.Weis,
A.T.Brünger,
J.J.Skehel,
D.C.Wiley.
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Ref.
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J Mol Biol, 1990,
212,
737-761.
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PubMed id
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Secondary reference #3
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Title
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Studies on the structure of the influenza virus haemagglutinin at the ph of membrane fusion.
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Authors
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R.W.Ruigrok,
A.Aitken,
L.J.Calder,
S.R.Martin,
J.J.Skehel,
S.A.Wharton,
W.Weis,
D.C.Wiley.
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Ref.
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J Gen Virol, 1988,
69,
2785-2795.
[DOI no: ]
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PubMed id
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Secondary reference #4
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Title
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Analyses of the antigenicity of influenza haemagglutinin at the ph optimum for virus-Mediated membrane fusion.
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Authors
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R.S.Daniels,
A.R.Douglas,
J.J.Skehel,
D.C.Wiley.
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Ref.
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J Gen Virol, 1983,
64,
1657-1662.
[DOI no: ]
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PubMed id
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Secondary reference #5
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Title
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Changes in the conformation of influenza virus hemagglutinin at the ph optimum of virus-Mediated membrane fusion.
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Authors
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J.J.Skehel,
P.M.Bayley,
E.B.Brown,
S.R.Martin,
M.D.Waterfield,
J.M.White,
I.A.Wilson,
D.C.Wiley.
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Ref.
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Proc Natl Acad Sci U S A, 1982,
79,
968-972.
[DOI no: ]
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PubMed id
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Secondary reference #6
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Title
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Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 a resolution.
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Authors
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I.A.Wilson,
J.J.Skehel,
D.C.Wiley.
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Ref.
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Nature, 1981,
289,
366-373.
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PubMed id
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