UniProt functional annotation for Q8NKX2



	UniProt functional annotation for Q8NKX2

UniProt code: Q8NKX2.

Organism: Streptococcus pyogenes serotype M18 (strain MGAS8232).

Taxonomy: Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus.

Function: Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.

Miscellaneous: Superantigen that binds to major histocompatibility complex class II beta chain in a zinc-dependent manner, it may activate up to 20% of all T-cells. Superantigens bind simultaneously TCRs and MHC class II molecules resulting in a massive release of pyrogenic and inflammatory cytokines.

Miscellaneous: This toxin seems to be coded by a bacteriophage.

Similarity: Belongs to the staphylococcal/streptococcal toxin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Streptococcus pyogenes serotype M18 (strain MGAS8232).
Taxonomy:		Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus.



Function:		Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.


Miscellaneous:		Superantigen that binds to major histocompatibility complex class II beta chain in a zinc-dependent manner, it may activate up to 20% of all T-cells. Superantigens bind simultaneously TCRs and MHC class II molecules resulting in a massive release of pyrogenic and inflammatory cytokines.
Miscellaneous:		This toxin seems to be coded by a bacteriophage.
Similarity:		Belongs to the staphylococcal/streptococcal toxin family. {ECO:0000305}.