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UniProt functional annotation for Q5SL87 | ||
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| UniProt code: Q5SL87. |
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| Organism: | |
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8). |
| Taxonomy: | |
Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus. |
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| Function: | |
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvB is a Mg(2+)- dependent, DNA-dependent ATPase with an equal preference for supercoiled and linear duplex DNA. It can promote Holliday junction migration alone. {ECO:0000255|HAMAP-Rule:MF_00016, ECO:0000269|PubMed:10485292}. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00016, ECO:0000269|PubMed:10485292}; |
| Activity regulation: | |
The activity of RuvB is enhanced by RuvA. {ECO:0000269|PubMed:10485292}. |
| Subunit: | |
Forms a complex with RuvA. {ECO:0000255|HAMAP-Rule:MF_00016, ECO:0000269|PubMed:10485292, ECO:0000269|PubMed:11171970}. |
| Similarity: | |
Belongs to the RuvB family. {ECO:0000255|HAMAP- Rule:MF_00016}. |
Annotations taken from UniProtKB at the EBI.