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PDBsum entry 1hle
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Hydrolase inhibitor(serine proteinase)
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PDB id
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1hle
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 a resolution.
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Authors
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U.Baumann,
W.Bode,
R.Huber,
J.Travis,
J.Potempa.
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Ref.
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J Mol Biol, 1992,
226,
1207-1218.
[DOI no: ]
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PubMed id
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Abstract
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The crystal structure of active-site cleaved equine leucocyte elastase
inhibitor, a member of the serpin superfamily, has been solved and refined to a
crystallographic R-factor of 17.6% at 1.95 A resolution. Despite being an
intracellular inhibitor with rather low sequence homology of 30% to human alpha
1-antichymotrypsin and alpha 1-proteinase inhibitor, the three-dimensional
structures are very similar, with deviations only at the sites of insertions and
few mobile secondary structure elements. The better resolution in comparison
with the structures of other cleaved serpins allows a more precise description
of the so-called R-state of the serpins.
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Figure 4.
Figure 4. equence alignment according to Huber & Carrel1 (1989) of some serpis
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Figure 5.
Fig. 5.
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The above figures are
reprinted
by permission from Elsevier:
J Mol Biol
(1992,
226,
1207-1218)
copyright 1992.
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