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UniProt functional annotation for P12318 | ||
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| UniProt code: P12318. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269|PubMed:19011614}. |
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| Subunit: | |
Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK. {ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:19011614, ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:8327512}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011614}. |
| Tissue specificity: | |
Found on monocytes, neutrophils and eosinophil platelets. |
| Ptm: | |
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK. {ECO:0000269|PubMed:8132624, ECO:0000269|PubMed:8756631}. |
| Sequence caution: | |
Sequence=AAA35932.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.