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UniProt functional annotation for P35030 | ||
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| UniProt code: P35030. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. {ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:14507909, ECO:0000269|PubMed:18077447, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0000269|PubMed:9099703}. |
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| Catalytic activity: | |
Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; Evidence={ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:14507909, ECO:0000269|PubMed:18077447, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0000269|PubMed:6698368, ECO:0000269|PubMed:9099703}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:14507909, ECO:0000269|PubMed:6698368}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896}; |
| Activity regulation: | |
Not inhibited by Kunitz-type trypsin inhibitors. {ECO:0000269|PubMed:18077447, ECO:0000269|PubMed:9099703}. |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 8.5. {ECO:0000269|PubMed:6698368}; |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:6698368}. |
| Tissue specificity: | |
Detected in pancreas and pancreatic fluid (at protein level) (PubMed:6698368). Expressed in pancreas and brain (PubMed:8294000). Detected in ileum (PubMed:12021776). {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:6698368, ECO:0000269|PubMed:8294000}. |
| Similarity: | |
Belongs to the peptidase S1 family. {ECO:0000255|PROSITE- ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.