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UniProt functional annotation for O89100 | ||
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| UniProt code: O89100. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
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| Subunit: | |
Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23 (By similarity). Interacts with phosphorylated LIME1 upon TCR activation. {ECO:0000250, ECO:0000269|PubMed:14610044}. |
| Subcellular location: | |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. |
| Similarity: | |
Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.