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UniProt functional annotation for P60849 | ||
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| UniProt code: P60849. |
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| Organism: | |
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus. |
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| Function: | |
Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. May be involved in DNA compaction. May bind rRNA and mRNA, playing a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes. |
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| Subunit: | |
Homotetramer. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. Chromosome {ECO:0000305}. |
| Ptm: | |
Acetylated. Deacetylation by the SIR2-homolog deacetylase increases its DNA-binding affinity, thereby repressing transcription. Regulation of DNA-based activities is therefore achieved at the chromatin level. {ECO:0000269|PubMed:11935028}. |
| Mass spectrometry: | |
Mass=10538; Method=MALDI; Evidence={ECO:0000269|PubMed:11935028}; |
| Similarity: | |
Belongs to the histone-like Alba family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAK41236.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.