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UniProt functional annotation for P04079 | ||
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| UniProt code: P04079. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Catalyzes the synthesis of GMP from XMP. |
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| Catalytic activity: | |
Reaction=ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate; Xref=Rhea:RHEA:11680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58115, ChEBI:CHEBI:58359, ChEBI:CHEBI:456215; EC=6.3.5.2; |
| Activity regulation: | |
Inhibited by 2-fluoroinosine 5'-monophosphate (F- IMP) and by N(2)-hydroxyguanosine 5'-monophosphate (N(2)-OH-GMP). {ECO:0000269|PubMed:9890911}. |
| Pathway: | |
Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. |
| Subunit: | |
Homodimer. |
| Induction: | |
Activated by cAMP receptor protein (CRP). Repressed by DnaA. |
Annotations taken from UniProtKB at the EBI.