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Contents |
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344 a.a.
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339 a.a.
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54 a.a.
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* Residue conservation analysis
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PDB id:
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Complex (gtp-binding/transducer)
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Title:
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G protein heterotrimer gi_alpha_1 beta_1 gamma_2 with gdp bound
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Structure:
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G protein gi alpha 1. Chain: a. Fragment: alpha 1. Engineered: yes. G protein gi beta 1. Chain: b. Fragment: beta 1. Engineered: yes. G protein gi gamma 2.
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Source:
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Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.
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Biol. unit:
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Trimer (from
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Resolution:
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2.30Å
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R-factor:
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0.226
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R-free:
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0.307
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Authors:
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M.A.Wall,S.R.Sprang
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Key ref:
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M.A.Wall
et al.
(1995).
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
Cell,
83,
1047-1058.
PubMed id:
DOI:
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Date:
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13-Nov-96
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Release date:
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12-Feb-97
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PROCHECK
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Headers
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References
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P10824
(GNAI1_RAT) -
Guanine nucleotide-binding protein G(i) subunit alpha-1 from Rattus norvegicus
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Seq:
Struc:
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354 a.a.
344 a.a.
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Enzyme class:
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Chains A, B, G:
E.C.?
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DOI no:
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Cell
83:1047-1058
(1995)
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PubMed id:
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| |
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The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
|
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M.A.Wall,
D.E.Coleman,
E.Lee,
J.A.Iñiguez-Lluhi,
B.A.Posner,
A.G.Gilman,
S.R.Sprang.
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ABSTRACT
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The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta
1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha
and beta, an extended interface between beta and nearly all of gamma, and
limited interaction of alpha with gamma. The major alpha/beta interface covers
switch II of alpha, and GTP-induced rearrangement of switch II causes subunit
dissociation during signaling. Alterations in GDP binding in the heterotrimer
(compared with alpha-GDP) explain stabilization of the inactive conformation of
alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold
beta propeller. The conserved cores of these motifs are a scaffold for display
of their more variable linkers on the exterior face of each propeller blade.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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|
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D.Wu,
Q.Hu,
Z.Yan,
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H.Deng,
J.Wang,
X.Deng,
and
Y.Shi
(2012).
Structural basis of ultraviolet-B perception by UVR8.
|
| |
Nature,
484,
214-219.
|
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|
PDB codes:
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|
|
|
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|
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C.Xu,
and
J.Min
(2011).
Structure and function of WD40 domain proteins.
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| |
Protein Cell,
2,
202-214.
|
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|
PDB codes:
|
|
|
|
|
|
|
|
K.Y.Chung,
S.G.Rasmussen,
T.Liu,
S.Li,
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D.Calinski,
B.K.Kobilka,
V.L.Woods,
and
R.K.Sunahara
(2011).
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
|
| |
Nature,
477,
611-615.
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L.M.Simpson,
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and
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and
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Conformational flexibility and binding interactions of the G protein βγ heterodimer.
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| |
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and
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(2011).
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
|
| |
Nature,
477,
549-555.
|
|
|
PDB code:
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|
|
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|
|
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Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
|
| |
Proc Natl Acad Sci U S A,
107,
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|
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|
PDB code:
|
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|
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|
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A.Strasser,
and
H.J.Wittmann
(2010).
Distinct interactions between the human adrenergic beta(2) receptor and Galpha(s)--an in silico study.
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| |
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16,
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and
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(2010).
NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.
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| |
Proc Natl Acad Sci U S A,
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PDB codes:
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J.J.Tesmer
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PDB codes:
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The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits.
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| |
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| |
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
