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Contents |
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338 a.a.
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339 a.a.
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58 a.a.
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* Residue conservation analysis
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PDB id:
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| Name: |
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Complex (gtp-binding/transducer)
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Title:
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Heterotrimeric complex of a gt-alpha/gi-alpha chimera and the gt-beta- gamma subunits
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Structure:
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Gt-alpha/gi-alpha chimera. Chain: a. Engineered: yes. Other_details: this is a chimeric protein where residues 216-294 of bovine gt alpha have been replaced with residues 220-298 of rat gi alpha 1. Gt-beta. Chain: b. Synonym: beta1, transducin beta subunit.
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Source:
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Fragment: 216 - 294. Bos taurus. Cattle. Organism_taxid: 9913. Organ: eye. Tissue: retina. Cell: rod. Organelle: rod outer segment. Expressed in: escherichia coli.
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Biol. unit:
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Hexamer (from
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Resolution:
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2.00Å
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R-factor:
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0.207
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R-free:
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0.295
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Authors:
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D.G.Lambright,J.Sondek,A.Bohm,N.P.Skiba,H.E.Hamm,P.B.Sigler
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Key ref:
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D.G.Lambright
et al.
(1996).
The 2.0 A crystal structure of a heterotrimeric G protein.
Nature,
379,
311-319.
PubMed id:
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Date:
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07-Aug-96
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Release date:
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12-Mar-97
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PROCHECK
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Headers
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References
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P04695
(GNAT1_BOVIN) -
Guanine nucleotide-binding protein G(t) subunit alpha-1 from Bos taurus
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Seq:
Struc:
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350 a.a.
338 a.a.*
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Nature
379:311-319
(1996)
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PubMed id:
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The 2.0 A crystal structure of a heterotrimeric G protein.
|
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D.G.Lambright,
J.Sondek,
A.Bohm,
N.P.Skiba,
H.E.Hamm,
P.B.Sigler.
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ABSTRACT
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The structure of a heterotrimeric G protein reveals the mechanism of the
nucleotide-dependent engagement of the alpha and beta gamma subunits that
regulates their interaction with receptor and effector molecules. The
interaction involves two distinct interfaces and dramatically alters the
conformation of the alpha but not of the beta gamma subunits. The location of
the known sites for post-translational modification and receptor coupling
suggest a plausible orientation with respect to the membrane surface and an
activated heptahelical receptor.
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Literature references that cite this PDB file's key reference
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| |
PubMed id
|
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Reference
|
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D.Urano,
N.Phan,
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(2012).
Endocytosis of the seven-transmembrane RGS1 protein activates G-protein-coupled signalling in Arabidopsis.
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| |
Nat Cell Biol,
14,
1079-1088.
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|
|
C.Xu,
and
J.Min
(2011).
Structure and function of WD40 domain proteins.
|
| |
Protein Cell,
2,
202-214.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
G.T.Johnson,
L.Autin,
D.S.Goodsell,
M.F.Sanner,
and
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(2011).
ePMV embeds molecular modeling into professional animation software environments.
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| |
Structure,
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Modeling GPCR active state conformations: The β(2) -adrenergic receptor.
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Proteins,
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and
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Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
|
| |
Proc Natl Acad Sci U S A,
107,
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|
PDB code:
|
|
|
|
|
|
|
|
A.V.Smrcka,
N.Kichik,
T.Tarragó,
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NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.
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Proc Natl Acad Sci U S A,
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WD40 proteins propel cellular networks.
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S.S.Li,
H.Wang,
and
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(2010).
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
|
| |
Proc Natl Acad Sci U S A,
107,
19266-19271.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.A.Gonçalves,
J.C.Borges,
J.C.Silva,
P.F.Papa,
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Solution structure of the human signaling protein RACK1.
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BMC Struct Biol,
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Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling.
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Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex.
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Passing the baton in class B GPCRs: peptide hormone activation via helix induction?
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Trends Biochem Sci,
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D.L.Yang,
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Y.L.Xu,
Y.H.Gao,
X.J.Yang,
X.Q.Hao,
M.Su,
X.Q.Wang,
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(2009).
Galphaq-Protein Carboxyl Terminus Imitation Polypeptide (GCIP)-27 Inhibits Right Ventricular Hypertrophy Induced by Monocrotaline in Rats.
|
| |
Biol Pharm Bull,
32,
376-381.
|
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|
|
|
|
E.J.Friedman,
B.R.Temple,
S.N.Hicks,
J.Sondek,
C.D.Jones,
and
A.M.Jones
(2009).
Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain.
|
| |
J Mol Biol,
392,
1044-1054.
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|
|
|
|
E.J.Heenan,
J.L.Vanhooke,
B.R.Temple,
L.Betts,
J.E.Sondek,
and
H.G.Dohlman
(2009).
Structure and function of Vps15 in the endosomal G protein signaling pathway.
|
| |
Biochemistry,
48,
6390-6401.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.E.Hamm,
S.M.Meier,
G.Liao,
and
A.M.Preininger
(2009).
Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.
|
| |
Protein Sci,
18,
2326-2335.
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|
|
K.Khafizov
(2009).
GoLoco motif proteins binding to Galpha(i1): insights from molecular simulations.
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J Mol Model,
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J.H.Park,
H.W.Choe,
O.P.Ernst,
K.P.Hofmann,
and
P.W.Hildebrand
(2009).
Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface.
|
| |
Proc Natl Acad Sci U S A,
106,
10660-10665.
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|
|
|
|
S.M.Coyle,
W.V.Gilbert,
and
J.A.Doudna
(2009).
Direct link between RACK1 function and localization at the ribosome in vivo.
|
| |
Mol Cell Biol,
29,
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|
|
|
PDB code:
|
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|
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|
|
|
W.E.McIntire
(2009).
Structural determinants involved in the formation and activation of G protein betagamma dimers.
|
| |
Neurosignals,
17,
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|
A.M.Preininger,
J.Parello,
S.M.Meier,
G.Liao,
and
H.E.Hamm
(2008).
Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins.
|
| |
Biochemistry,
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|
|
A.R.Zurita,
and
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(2008).
The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits.
|
| |
Proc Natl Acad Sci U S A,
105,
2363-2368.
|
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|
|
|
|
|
A.V.Smrcka
(2008).
G protein betagamma subunits: central mediators of G protein-coupled receptor signaling.
|
| |
Cell Mol Life Sci,
65,
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|
|
A.V.Smrcka,
D.M.Lehmann,
and
A.L.Dessal
(2008).
G protein betagamma subunits as targets for small molecule therapeutic development.
|
| |
Comb Chem High Throughput Screen,
11,
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|
|
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|
|
|
|
C.A.Johnston,
K.Afshar,
J.T.Snyder,
G.G.Tall,
P.Gönczy,
D.P.Siderovski,
and
F.S.Willard
(2008).
Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.
|
| |
J Biol Chem,
283,
21550-21558.
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|
|
PDB codes:
|
|
|
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|
|
D.Rakotobe,
S.Violot,
S.S.Hong,
P.Gouet,
and
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(2008).
Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.
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Virol J,
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E.McCusker,
and
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Refolding of G protein alpha subunits from inclusion bodies expressed in Escherichia coli.
|
| |
Protein Expr Purif,
58,
342-355.
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F.Marziale,
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and
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Different roles of two gamma-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii: remodelling of interaction surfaces may enhance microtubule nucleation at low temperature.
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FEBS J,
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A.J.Kimple,
J.M.Conley,
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M.D.Willard,
V.J.Watts,
N.A.Lambert,
S.R.Ikeda,
Q.Du,
and
D.P.Siderovski
(2008).
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
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| |
J Biol Chem,
283,
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Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus.
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Vision Res,
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D.L.Armstrong,
and
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(2008).
Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana.
|
| |
Protein Sci,
17,
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PDB code:
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|
K.Sayar,
O.Uğur,
T.Liu,
V.J.Hilser,
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Exploring allosteric coupling in the alpha-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches.
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(2008).
N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).
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| |
Cell Signal,
20,
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| |
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PDB code:
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|
|
|
|
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|
|
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| |
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(2008).
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|
| |
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PDB code:
|
|
|
|
|
|
|
|
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and
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|
| |
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|
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| |
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58,
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|
|
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(2007).
Dynamic integration of alpha-adrenergic and cholinergic signals in the atria: role of G protein-regulated inwardly rectifying K+ channels.
|
| |
J Biol Chem,
282,
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F.Barceló,
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and
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(2007).
Interaction of the C-terminal region of the Ggamma protein with model membranes.
|
| |
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93,
2530-2541.
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|
F.Mancia,
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(2007).
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|
| |
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|
|
H.G.Zhang,
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J.Z.Zhou,
Y.Liu,
Y.Jia,
and
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(2007).
G(alphaq)-protein carboxyl terminus imitation polypeptide GCIP-27 attenuates cardiac hypertrophy in vitro and in vivo.
|
| |
Clin Exp Pharmacol Physiol,
34,
1276-1281.
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|
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M.Boxus,
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F.Dequiedt,
J.F.Dewulf,
J.Duchateau,
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M.Parmentier,
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and
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(2007).
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.
|
| |
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|
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(2007).
Macromolecular recognition in the Protein Data Bank.
|
| |
Acta Crystallogr D Biol Crystallogr,
63,
1-8.
|
|
|
|
|
|
|
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J.L.Spudich,
and
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(2007).
Crystal structure of the Anabaena sensory rhodopsin transducer.
|
| |
J Mol Biol,
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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