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UniProt functional annotation for Q92837 | ||
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| UniProt code: Q92837. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. {ECO:0000269|PubMed:12556519}. |
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| Subunit: | |
Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation. {ECO:0000269|PubMed:11738041}. |
| Subcellular location: | |
Cytoplasm. |
| Ptm: | |
Phosphorylated. {ECO:0000250}. |
| Similarity: | |
Belongs to the GSK-3-binding protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.