PDBsum entry 1ghb

Hydrolase/hydrolase inhibitor

PDB id: 1ghb

Contents

Protein chains

11 a.a. *

131 a.a. *

95 a.a. *

Ligands

PRO-GLY-ALA

ACE-TRP

HEX ×5

IPA ×3

Waters ×309

* Residue conservation analysis

PDB id:

1ghb

Name:

Hydrolase/hydrolase inhibitor

Title:

A second active site in chymotrypsin? the x-ray crystal structure of n-acetyl-d-tryptophan bound to gamma-chymotrypsin

Structure:

Gamma-chymotrypsin. Chain: e. Gamma-chymotrypsin. Chain: f. Gamma-chymotrypsin. Chain: g. Pro-gly-ala. Chain: p. Engineered: yes

Source:

Bos taurus. Organism_taxid: 9913.

Biol. unit:

Tetramer (from PQS)

Resolution:

2.00Å R-factor: 0.152

Authors:

H.P.Yennawar,N.H.Yennawar,G.K.Farber

Key ref:

H.P.Yennawar et al. (1995). A structural explanation for enzyme memory in nonaqueous solvents.. J am chem soc, 117, 577-585.

Date:

06-Apr-94 Release date: 22-Jun-94

Protein chain

P00766  (CTRA_BOVIN) -  Chymotrypsinogen A from Bos taurus

Seq: 245 a.a.

Struc: 11 a.a.

Protein chain

P00766  (CTRA_BOVIN) -  Chymotrypsinogen A from Bos taurus

Seq: 245 a.a.

Struc: 131 a.a.

Protein chain

P00766  (CTRA_BOVIN) -  Chymotrypsinogen A from Bos taurus

Seq: 245 a.a.

Struc: 95 a.a.

Enzyme reactions

• Enzyme class: Chains E, F, G: E.C.3.4.21.1 - chymotrypsin.
• Reaction: Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.