UniProt functional annotation for P00921

UniProt code: P00921.

Organism: Bos taurus (Bovine).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
 
Function: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. {ECO:0000250}.
 
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.
Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme regulation: Inhibited by acetazolamide. {ECO:0000250}.
Subunit: Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity (By similarity). {ECO:0000250}.
Subcellular location: Cytoplasm.
Miscellaneous: One minor and two major forms were isolated chromatographically.
Similarity: Belongs to the alpha-carbonic anhydrase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.