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UniProt functional annotation for P70604 | ||
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| UniProt code: P70604. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. |
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| Subunit: | |
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding. {ECO:0000269|PubMed:9774106}. |
| Subcellular location: | |
Membrane; Multi-pass membrane protein. |
| Tissue specificity: | |
Brain. |
| Similarity: | |
Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.