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UniProt functional annotation for P48059 | ||
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| UniProt code: P48059. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. |
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| Subunit: | |
Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors. {ECO:0000250, ECO:0000269|PubMed:10022929, ECO:0000269|PubMed:19074270, ECO:0000269|PubMed:19117955, ECO:0000269|PubMed:9843575}. |
| Subcellular location: | |
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Tissue specificity: | |
Expressed in most tissues except in the brain. |
Annotations taken from UniProtKB at the EBI.