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UniProt functional annotation for Q93K97 | ||
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| UniProt code: Q93K97. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. {ECO:0000269|PubMed:11416161}. |
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| Catalytic activity: | |
Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+); Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=3.6.1.13; Evidence={ECO:0000269|PubMed:11323725}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11323725, ECO:0000269|PubMed:12135348}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000269|PubMed:11323725, ECO:0000269|PubMed:12135348}; |
| Activity regulation: | |
Inhibited by phosphorylated compounds such as AMP, ADP, ATP, 3-phosphoglyceric acid and PPi. Not inhibited by orthophosphate. Activity is high in cells grown in low glucose concentrations and decreases dramatically as glucose concentration increases. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:11323725, ECO:0000269|PubMed:12135348}. |
| Similarity: | |
Belongs to the Nudix hydrolase family. NudF subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.