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UniProt functional annotation for P21734 | ||
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| UniProt code: P21734. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER- membrane proteins with misfolded transmembrane domains (ERAD-M). {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:10878801, ECO:0000269|PubMed:11146622}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin- activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin- conjugating enzyme]-L-cysteine.; EC=2.3.2.23; Evidence={ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE- ProRule:PRU10133}; |
| Pathway: | |
Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. |
| Developmental stage: | |
Early stages of growth after spore germination. |
| Induction: | |
By heat shock and cadmium. |
| Miscellaneous: | |
Present with 8940 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the ubiquitin-conjugating enzyme family. {ECO:0000255|PROSITE-ProRule:PRU00388}. |
Annotations taken from UniProtKB at the EBI.