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PDBsum entry 1fvb
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Immunoglobulin
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PDB id
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1fvb
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References listed in PDB file
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Key reference
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Title
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Model-Building study of the combining sites of two antibodies to alpha (1----6)dextran.
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Authors
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E.A.Padlan,
E.A.Kabat.
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Ref.
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Proc Natl Acad Sci U S A, 1988,
85,
6885-6889.
[DOI no: ]
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PubMed id
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Abstract
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Models of the Fv portion (containing the variable regions of the heavy and light
chains) of two monoclonal anti-alpha (1----6)dextran antibodies, W3129 and
19.1.2, were constructed from amino acid sequences and the known
three-dimensional structures of the Fv portions of McPC603 and J539. The modeled
combining site of W3129 has a protrusion on one side, formed by the long
complementarity-determining region 1 of the light chain and the long
complementarity-determining region 3 of the heavy chain, and has a cavity
accommodating a glucose moiety. The model of the 19.1.2 site is basically flat
with a shallow groove that can accommodate several internal glucose units. These
results support the earlier conclusions, from ligand binding data, that W3129
has a cavity-type site, involving the terminal nonreducing glucose residue
(endbinder), whereas 19.1.2 has a groove-type site.
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