UniProt functional annotation for P03077



	UniProt functional annotation for P03077

UniProt code: P03077.

Organism: Murine polyomavirus (strain A2) (MPyV).

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Alphapolyomavirus.

Function: Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase- associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT plays also a role in regulation of early and late gene expression and in viral DNA replication. {ECO:0000269|PubMed:16840310}.

Subunit: Interacts with host Ppp2/PP2A A and C subunits; this interaction alters Ppp2/PP2A substrate specificity and localization. Interacts with host Src, Yes1, and Fyn. Interacts with host Shc1, Plcg1 and p85; these interactions lead to cell cycle progression. Interacts with host 14-3-3 proteins. {ECO:0000269|PubMed:2153055, ECO:0000269|PubMed:2463167, ECO:0000269|PubMed:3027584, ECO:0000269|PubMed:6304524, ECO:0000269|PubMed:7759472, ECO:0000269|PubMed:8022784, ECO:0000269|PubMed:8036498}.

Subcellular location: Host membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Domain: The NPTY motif is required for interaction with host Shc1 protein. {ECO:0000269|PubMed:8022784}.

Ptm: Tyrosine-phosphorylated on three residues 250, 315 and 322, providing docking sites for host Shc1, p85, and Plcg1, respectively. {ECO:0000269|PubMed:7759472, ECO:0000269|PubMed:8022784, ECO:0000269|PubMed:9420259}.

Annotations taken from UniProtKB at the EBI.


Organism:		Murine polyomavirus (strain A2) (MPyV).
Taxonomy:		Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Alphapolyomavirus.



Function:		Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase- associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT plays also a role in regulation of early and late gene expression and in viral DNA replication. {ECO:0000269\|PubMed:16840310}.


Subunit:		Interacts with host Ppp2/PP2A A and C subunits; this interaction alters Ppp2/PP2A substrate specificity and localization. Interacts with host Src, Yes1, and Fyn. Interacts with host Shc1, Plcg1 and p85; these interactions lead to cell cycle progression. Interacts with host 14-3-3 proteins. {ECO:0000269\|PubMed:2153055, ECO:0000269\|PubMed:2463167, ECO:0000269\|PubMed:3027584, ECO:0000269\|PubMed:6304524, ECO:0000269\|PubMed:7759472, ECO:0000269\|PubMed:8022784, ECO:0000269\|PubMed:8036498}.
Subcellular location:		Host membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Domain:		The NPTY motif is required for interaction with host Shc1 protein. {ECO:0000269\|PubMed:8022784}.
Ptm:		Tyrosine-phosphorylated on three residues 250, 315 and 322, providing docking sites for host Shc1, p85, and Plcg1, respectively. {ECO:0000269\|PubMed:7759472, ECO:0000269\|PubMed:8022784, ECO:0000269\|PubMed:9420259}.