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PDBsum entry 1fmk
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Phosphotransferase
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PDB id
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1fmk
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References listed in PDB file
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Key reference
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Title
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Three-Dimensional structure of the tyrosine kinase c-Src.
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Authors
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W.Xu,
S.C.Harrison,
M.J.Eck.
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Ref.
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Nature, 1997,
385,
595-602.
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PubMed id
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Abstract
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The structure of a large fragment of the c-Src tyrosine kinase, comprising the
regulatory and kinase domains and the carboxy-terminal tall, has been determined
at 1.7 A resolution in a closed, inactive state. Interactions among domains,
stabilized by binding of the phosphorylated tail to the SH2 domain, lock the
molecule in a conformation that simultaneously disrupts the kinase active site
and sequesters the binding surfaces of the SH2 and SH3 domains. The structure
shows how appropriate cellular signals, or transforming mutations in v-Src,
could break these interactions to produce an open, active kinase.
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