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UniProt functional annotation for P07975 | ||
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| UniProt code: P07975. |
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| Organism: | |
Influenza C virus (strain C/Johannesburg/1/1966). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus. |
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| Function: | |
Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O- acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. {ECO:0000255|HAMAP-Rule:MF_04072}. |
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| Catalytic activity: | |
Reaction=H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N- acetylneuraminate; Xref=Rhea:RHEA:22600, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28999, ChEBI:CHEBI:30089, ChEBI:CHEBI:35418; EC=3.1.1.53; Evidence={ECO:0000255|HAMAP- Rule:MF_04072}; |
| Catalytic activity: | |
Reaction=H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N- acetylneuraminate; Xref=Rhea:RHEA:25564, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29006, ChEBI:CHEBI:30089, ChEBI:CHEBI:35418; EC=3.1.1.53; Evidence={ECO:0000255|HAMAP- Rule:MF_04072}; |
| Subunit: | |
Homotrimer of disulfide-linked HEF1-HEF2. {ECO:0000255|HAMAP- Rule:MF_04072}. |
| Subcellular location: | |
Virion membrane {ECO:0000255|HAMAP- Rule:MF_04072}; Single-pass type I membrane protein {ECO:0000255|HAMAP- Rule:MF_04072}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04072}; Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04072}. |
| Ptm: | |
In natural infection, inactive HEF is matured into HEF1 and HEF2 outside the cell by one or more trypsin-like, arginine-specific endoprotease. {ECO:0000255|HAMAP-Rule:MF_04072}. |
| Similarity: | |
Belongs to the influenza viruses hemagglutinin family. {ECO:0000255|HAMAP-Rule:MF_04072}. |
Annotations taken from UniProtKB at the EBI.