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UniProt functional annotation for Q08484 | ||
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| UniProt code: Q08484. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
GTPase-activating protein (GAP) that stimulates specifically the intrinsic GTPase activity of Ypt/Rab-type GTPases YPT1 and YPT7 (PubMed:11359917, PubMed:19386605). Functions on the Golgi as a negative regulator of YPT1 (PubMed:11359917). Functions on the vacuole as a negative regulator of YPT7 (PubMed:11118206, PubMed:19386605). It is also active on SEC4 and YPT51 (PubMed:10508155). Provides a catalytic arginine (arginine finger) and glutamine (glutamine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable) (PubMed:16855591). {ECO:0000269|PubMed:10508155, ECO:0000269|PubMed:11118206, ECO:0000269|PubMed:11359917, ECO:0000269|PubMed:16855591, ECO:0000269|PubMed:19386605, ECO:0000305|PubMed:10508155}. |
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| Subcellular location: | |
Golgi apparatus, Golgi stack {ECO:0000269|PubMed:11359917}. |
| Miscellaneous: | |
Present with 206 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
Annotations taken from UniProtKB at the EBI.