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UniProt functional annotation for P0A6T5 | ||
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| UniProt code: P0A6T5. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Catalytic activity: | |
Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16; |
| Activity regulation: | |
Allosteric enzyme. Activity is modulated by K(+), divalent cations, UTP, and tetrahydrobiopterin. Tetrahydrobiopterin is an inhibitor of this enzyme. |
| Pathway: | |
Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. |
| Subunit: | |
Toroid-shaped homodecamer, composed of two pentamers of five dimers. {ECO:0000269|PubMed:11087827, ECO:0000269|PubMed:12297008}. |
| Similarity: | |
Belongs to the GTP cyclohydrolase I family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.