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UniProt functional annotation for Q9UN19 | ||
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| UniProt code: Q9UN19. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269|PubMed:10770799}. |
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| Subunit: | |
Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2. {ECO:0000269|PubMed:10432293, ECO:0000269|PubMed:10770799, ECO:0000269|PubMed:10983984}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:10770799}. Membrane {ECO:0000269|PubMed:10770799}; Peripheral membrane protein {ECO:0000269|PubMed:10770799}. Note=Membrane-associated after cell stimulation leading to its translocation. |
| Tissue specificity: | |
Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. {ECO:0000269|PubMed:10432293}. |
| Induction: | |
Upon B-cell activation. |
| Ptm: | |
Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:10770799}. |
Annotations taken from UniProtKB at the EBI.