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UniProt functional annotation for P05710 | ||
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| UniProt code: P05710. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
This is a receptor for the anterior pituitary hormone prolactin. |
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| Subunit: | |
Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent. {ECO:0000250}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Domain: | |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Domain: | |
The box 1 motif is required for JAK interaction and/or activation. |
| Similarity: | |
Belongs to the type I cytokine receptor family. Type 1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.