UniProt functional annotation for P51452

UniProt code: P51452.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Subunit: Interacts with VRK3, which seems to activate it's phosphatase activity (By similarity).
Subcellular location: Nucleus.
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Similarity: Contains 1 tyrosine-protein phosphatase domain.

Annotations taken from UniProtKB at the EBI.