UniProt functional annotation for P05187

UniProt code: P05187.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Catalytic activity: A phosphate monoester + H(2)O = an alcohol + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10042}.
Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion.;
Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions.;
Subunit: Homodimer. {ECO:0000269|PubMed:11124260, ECO:0000269|PubMed:15946677, ECO:0000269|PubMed:16815919, ECO:0000269|PubMed:20693656}.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue specificity: Detected in placenta (at protein level). {ECO:0000269|PubMed:20693656}.
Polymorphism: Placental ALP is highly polymorphic, there are at least three common alleles.
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).
Similarity: Belongs to the alkaline phosphatase family. {ECO:0000305}.
Sequence caution: Sequence=AAA51708.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.