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UniProt functional annotation for P13725 | ||
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| UniProt code: P13725. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:1542792, ECO:0000269|PubMed:1542793}. |
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| Subcellular location: | |
Secreted. |
| Ptm: | |
Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity. {ECO:0000269|PubMed:2325640}. |
| Similarity: | |
Belongs to the LIF/OSM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.