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UniProt functional annotation for Q57366 | ||
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| UniProt code: Q57366. |
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| Organism: | |
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides). |
| Taxonomy: | |
Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; Rhodobacteraceae; Luteovulum. |
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| Function: | |
Catalyzes the reduction of dimethyl sulfoxide (DMSO) and trimethylamine N-oxide (TMAO) to dimethyl sulfide (DMS) and trimethylamine, respectively. The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO and TMAO. {ECO:0000269|PubMed:9401017}. |
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| Catalytic activity: | |
Reaction=a menaquinone + dimethyl sulfide + H2O = a menaquinol + dimethyl sulfoxide; Xref=Rhea:RHEA:28494, Rhea:RHEA-COMP:9537, Rhea:RHEA-COMP:9539, ChEBI:CHEBI:15377, ChEBI:CHEBI:16374, ChEBI:CHEBI:17437, ChEBI:CHEBI:18151, ChEBI:CHEBI:28262; EC=1.8.5.3; |
| Catalytic activity: | |
Reaction=2 [Fe(III)cytochrome c] + H2O + trimethylamine = 2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide; Xref=Rhea:RHEA:24236, Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15724, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:58389; EC=1.7.2.3; |
| Cofactor: | |
Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000269|PubMed:1710616, ECO:0000269|PubMed:2326278, ECO:0000269|Ref.8}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo- bis-MGD) cofactor per subunit. {ECO:0000269|PubMed:1710616, ECO:0000269|PubMed:2326278, ECO:0000269|Ref.8}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:8658134, ECO:0000269|Ref.8}. |
| Subcellular location: | |
Periplasm {ECO:0000269|PubMed:1710616}. |
| Ptm: | |
Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. |
| Disruption phenotype: | |
Disruption of dmsA results in the inability to use DMSO or TMAO as the terminal electron acceptor in anaerobic respiration and in greatly diminished in vitro DMSOR activity. {ECO:0000269|PubMed:9401017}. |
| Similarity: | |
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.