UniProt functional annotation for P07476

UniProt code: P07476.

Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function:		Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subunit:		Directly or indirectly cross-linked to cornifelin (CNFN).
Subcellular location:		Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
Tissue specificity:		Keratinocytes of epidermis and other stratified squamous epithelia.
Ptm:		Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
Similarity:		Belongs to the involucrin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.