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UniProt functional annotation for P16581 | ||
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| UniProt code: P16581. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848, ECO:0000269|PubMed:28011641}. |
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| Subunit: | |
Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction. {ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:18606703}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:12649084, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein. |
| Polymorphism: | |
A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149). {ECO:0000269|PubMed:12649084, ECO:0000269|PubMed:7533025}. |
| Similarity: | |
Belongs to the selectin/LECAM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.