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PDBsum entry 1esl
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Cell adhesion protein
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PDB id
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1esl
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References listed in PDB file
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Key reference
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Title
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Insight into e-Selectin/ligand interaction from the crystal structure and mutagenesis of the lec/egf domains.
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Authors
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B.J.Graves,
R.L.Crowther,
C.Chandran,
J.M.Rumberger,
S.Li,
K.S.Huang,
D.H.Presky,
P.C.Familletti,
B.A.Wolitzky,
D.K.Burns.
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Ref.
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Nature, 1994,
367,
532-538.
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PubMed id
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Abstract
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The three-dimensional structure of the ligand-binding region of human E-selectin
has been determined at 2.0 A resolution. The structure reveals limited contact
between the two domains and a coordination of Ca2+ not predicted from other
C-type lectins. Structure/function analysis indicates a defined region and
specific amino-acid side chains that may be involved in ligand binding. These
features of the E-selectin/ligand interaction have important implications for
understanding the recruitment of leukocytes to sites of inflammation.
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Secondary reference #1
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Title
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Consensus repeat domains of e-Selectin enhance ligand binding.
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Authors
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S.H.Li,
D.K.Burns,
J.M.Rumberger,
D.H.Presky,
V.L.Wilkinson,
M.Anostario,
B.A.Wolitzky,
C.R.Norton,
P.C.Familletti,
K.J.Kim.
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Ref.
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J Biol Chem, 1994,
269,
4431-4437.
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PubMed id
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