UniProt functional annotation for Q05329

UniProt code: Q05329.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Catalyzes the production of GABA.
 
Catalytic activity: L-glutamate = 4-aminobutanoate + CO(2).
Cofactor: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:17384644};
Biophysicochemical properties: Kinetic parameters: KM=2.15 mM for glutamate {ECO:0000269|PubMed:8999827};
Subunit: Homodimer. {ECO:0000269|PubMed:10775108, ECO:0000269|PubMed:17384644}.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:12356867}. Cytoplasmic vesicle {ECO:0000269|PubMed:12356867}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:12356867}; Lipid-anchor {ECO:0000269|PubMed:12356867}. Golgi apparatus membrane {ECO:0000269|PubMed:12356867}; Peripheral membrane protein {ECO:0000269|PubMed:12356867}; Cytoplasmic side {ECO:0000269|PubMed:12356867}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Ptm: Phosphorylated; which does not affect kinetic parameters or subcellular location. {ECO:0000269|PubMed:8999827}.
Ptm: Palmitoylated; which is required for presynaptic clustering. {ECO:0000269|PubMed:12356867}.
Similarity: Belongs to the group II decarboxylase family. {ECO:0000305}.
Sequence caution: Sequence=CAA49554.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.