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UniProt functional annotation for P15024 | ||
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| UniProt code: P15024. |
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| Organism: | |
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes; Reovirales; Reoviridae; Spinareovirinae; Orthoreovirus. |
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| Function: | |
Inner capsid (core) component. Displays NTPase, RNA 5'- triphosphatase (RTPase) and RNA helicase activities and probably participates in transcription of the viral genome. Helicase activity might be involved in unwinding or reannealing dsRNA during RNA synthesis. RTPase enzymatic activity represents the first step in RNA capping, which yields a 5'-diphosphorylated plus-strand RNA. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| Subunit: | |
Interacts with protein mu-NS; in viral inclusions. {ECO:0000250}. |
| Subcellular location: | |
Virion {ECO:0000305}. Note=Found in the inner capsid (120 copies). |
| Similarity: | |
Belongs to the orthoreovirus lambda-1 protein family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA47271.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.