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PDBsum entry 1edh
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Cell adhesion protein
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PDB id
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1edh
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Contents |
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* Residue conservation analysis
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Nature
380:360-364
(1996)
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PubMed id:
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Structural basis of calcium-induced E-cadherin rigidification and dimerization.
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B.Nagar,
M.Overduin,
M.Ikura,
J.M.Rini.
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ABSTRACT
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The cadherins mediate cell adhesion and play a fundamental role in normal
development. They participate in the maintenance of proper cell-cell contacts:
for example, reduced levels of epithelial cadherin (E-cadherin) correlate with
increased invasiveness in many human tumour cell types. The cadherins typically
consist of five tandemly repeated extracellular domains, a single
membrane-spanning segment and a cytoplasmic region. The N-terminal extracellular
domains mediate cell-cell contact while the cytoplasmic region interacts with
the cytoskeleton through the catenins. Cadherins depend on calcium for their
function: removal of calcium abolishes adhesive activity, renders cadherins
vulnerable to proteases (reviewed in ref. 4) and, in E-cadherin, induces a
dramatic reversible conformational change in the entire extracellular region. We
report here the X-ray crystal structure at 2.0 A resolution of the two
N-terminal extracellular domains of E-cadherin in the presence of calcium. The
structure reveals a two-fold symmetric dimer, each molecule of which binds a
contiguous array of three bridged calcium ions. Not only do the bound calcium
ions linearize and rigidify the molecule, they promote dimerization. Although
the N-terminal domain of each molecule in the dimer is aligned in a parallel
orientation, the interactions between them differ significantly from those found
in the neural cadherin (N-cadherin) N-terminal domain (NCD1) structure. The
E-cadherin dual-domain structure reported here defines the role played by
calcium in the cadherin-mediated formation and maintenance of solid tissues.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.Brasch,
O.J.Harrison,
G.Ahlsen,
S.M.Carnally,
R.M.Henderson,
B.Honig,
and
L.Shapiro
(2011).
Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.
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J Mol Biol,
408,
57-73.
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PDB code:
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J.Vendome,
S.Posy,
X.Jin,
F.Bahna,
G.Ahlsen,
L.Shapiro,
and
B.Honig
(2011).
Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins.
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Nat Struct Mol Biol,
18,
693-700.
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PDB code:
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S.Hong,
R.B.Troyanovsky,
and
S.M.Troyanovsky
(2011).
Cadherin exits the junction by switching its adhesive bond.
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J Cell Biol,
192,
1073-1083.
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A.Pertsinidis,
Y.Zhang,
and
S.Chu
(2010).
Subnanometre single-molecule localization, registration and distance measurements.
|
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Nature,
466,
647-651.
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B.Bartelt-Kirbach,
K.Langer-Fischer,
and
N.Golenhofen
(2010).
Different regulation of N-cadherin and cadherin-11 in rat hippocampus.
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Cell Commun Adhes,
17,
75-82.
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C.Ciatto,
F.Bahna,
N.Zampieri,
H.C.VanSteenhouse,
P.S.Katsamba,
G.Ahlsen,
O.J.Harrison,
J.Brasch,
X.Jin,
S.Posy,
J.Vendome,
B.Ranscht,
T.M.Jessell,
B.Honig,
and
L.Shapiro
(2010).
T-cadherin structures reveal a novel adhesive binding mechanism.
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Nat Struct Mol Biol,
17,
339-347.
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PDB codes:
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D.Garrod
(2010).
Desmosomes in vivo.
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Dermatol Res Pract,
2010,
212439.
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D.Schreiner,
and
J.A.Weiner
(2010).
Combinatorial homophilic interaction between {gamma}-protocadherin multimers greatly expands the molecular diversity of cell adhesion.
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Proc Natl Acad Sci U S A,
107,
14893-14898.
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G.R.Owen,
and
D.L.Stokes
(2010).
Exploring the Nature of Desmosomal Cadherin Associations in 3D.
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Dermatol Res Pract,
2010,
930401.
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H.M.Elledge,
P.Kazmierczak,
P.Clark,
J.S.Joseph,
A.Kolatkar,
P.Kuhn,
and
U.Müller
(2010).
Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.
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Proc Natl Acad Sci U S A,
107,
10708-10712.
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PDB code:
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J.Yamagami,
A.S.Payne,
S.Kacir,
K.Ishii,
D.L.Siegel,
and
J.R.Stanley
(2010).
Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity.
|
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J Clin Invest,
120,
4111-4117.
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L.A.Chtcheglova,
L.Wildling,
J.Waschke,
D.Drenckhahn,
and
P.Hinterdorfer
(2010).
AFM functional imaging on vascular endothelial cells.
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J Mol Recognit,
23,
589-596.
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M.Sotomayor,
W.A.Weihofen,
R.Gaudet,
and
D.P.Corey
(2010).
Structural determinants of cadherin-23 function in hearing and deafness.
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Neuron,
66,
85.
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PDB codes:
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O.J.Harrison,
F.Bahna,
P.S.Katsamba,
X.Jin,
J.Brasch,
J.Vendome,
G.Ahlsen,
K.J.Carroll,
S.R.Price,
B.Honig,
and
L.Shapiro
(2010).
Two-step adhesive binding by classical cadherins.
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Nat Struct Mol Biol,
17,
348-357.
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PDB codes:
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T.Padilla-Benavides,
M.L.Roldán,
I.Larre,
D.Flores-Benitez,
N.Villegas-Sepúlveda,
R.G.Contreras,
M.Cereijido,
and
L.Shoshani
(2010).
The polarized distribution of Na+,K+-ATPase: role of the interaction between {beta} subunits.
|
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Mol Biol Cell,
21,
2217-2225.
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K.Pilichou,
C.A.Remme,
C.Basso,
M.E.Campian,
S.Rizzo,
P.Barnett,
B.P.Scicluna,
B.Bauce,
M.J.van den Hoff,
J.M.de Bakker,
H.L.Tan,
M.Valente,
A.Nava,
A.A.Wilde,
A.F.Moorman,
G.Thiene,
and
C.R.Bezzina
(2009).
Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy.
|
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J Exp Med,
206,
1787-1802.
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K.Zheng,
J.S.Laurence,
K.Kuczera,
G.Verkhivker,
C.R.Middaugh,
and
T.J.Siahaan
(2009).
Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides.
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Chem Biol Drug Des,
73,
584-598.
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L.Shapiro,
and
W.I.Weis
(2009).
Structure and biochemistry of cadherins and catenins.
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Cold Spring Harbor Perspect Biol,
1,
a003053.
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M.Trivedi,
R.A.Davis,
Y.Shabaik,
A.Roy,
G.Verkhivker,
J.S.Laurence,
C.R.Middaugh,
and
T.J.Siahaan
(2009).
The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin.
|
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J Pharm Sci,
98,
3562-3574.
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P.Hulpiau,
and
F.van Roy
(2009).
Molecular evolution of the cadherin superfamily.
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Int J Biochem Cell Biol,
41,
349-369.
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R.M.Harmon,
B.V.Desai,
and
K.J.Green
(2009).
Regulatory roles of the cadherin superfamily.
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F1000 Biol Rep,
1,
0.
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T.Inoue,
N.Okino,
Y.Kakuta,
A.Hijikata,
H.Okano,
H.M.Goda,
M.Tani,
N.Sueyoshi,
K.Kambayashi,
H.Matsumura,
Y.Kai,
and
M.Ito
(2009).
Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.
|
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J Biol Chem,
284,
9566-9577.
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PDB codes:
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W.M.Heupel,
T.Müller,
A.Efthymiadis,
E.Schmidt,
D.Drenckhahn,
and
J.Waschke
(2009).
Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus.
|
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J Biol Chem,
284,
8589-8595.
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Y.Li,
M.Hofmann,
Q.Wang,
L.Teng,
L.K.Chlewicki,
H.Pircher,
and
R.A.Mariuzza
(2009).
Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.
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Immunity,
31,
35-46.
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PDB codes:
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Y.Zhang,
S.Sivasankar,
W.J.Nelson,
and
S.Chu
(2009).
Resolving cadherin interactions and binding cooperativity at the single-molecule level.
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Proc Natl Acad Sci U S A,
106,
109-114.
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C.B.Lira,
K.Chu,
Y.C.Lee,
M.C.Hu,
and
S.H.Lin
(2008).
Expression of the extracellular domain of OB-cadherin as an Fc fusion protein using bicistronic retroviral expression vector.
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Protein Expr Purif,
61,
220-226.
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F.Zhou,
J.Su,
L.Fu,
Y.Yang,
L.Zhang,
L.Wang,
H.Zhao,
D.Zhang,
Z.Li,
and
X.Zha
(2008).
Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD.
|
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Glycoconj J,
25,
727-740.
|
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J.S.Yu,
S.Koujak,
S.Nagase,
C.M.Li,
T.Su,
X.Wang,
M.Keniry,
L.Memeo,
A.Rojtman,
M.Mansukhani,
H.Hibshoosh,
B.Tycko,
and
R.Parsons
(2008).
PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer.
|
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Oncogene,
27,
4657-4665.
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L.A.Taneyhill
(2008).
To adhere or not to adhere: the role of Cadherins in neural crest development.
|
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Cell Adh Migr,
2,
223-230.
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M.Auer,
A.J.Koster,
U.Ziese,
C.Bajaj,
N.Volkmann,
d.a. .N.Wang,
and
A.J.Hudspeth
(2008).
Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography.
|
| |
J Assoc Res Otolaryngol,
9,
215-224.
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M.Sotomayor,
and
K.Schulten
(2008).
The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin.
|
| |
Biophys J,
94,
4621-4633.
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S.Bibert,
H.Ayari,
D.Riveline,
E.Concord,
B.Hermant,
T.Vernet,
and
D.Gulino-Debrac
(2008).
Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin.
|
| |
J Biochem,
143,
821-832.
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S.Posy,
L.Shapiro,
and
B.Honig
(2008).
Sequence and structural determinants of strand swapping in cadherin domains: do all cadherins bind through the same adhesive interface?
|
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J Mol Biol,
378,
954-968.
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T.A.Tran,
and
J.A.Carlson
(2008).
Plasmacytoid squamous cell carcinoma of the vulva.
|
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Int J Gynecol Pathol,
27,
601-605.
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V.Z.Miloushev,
F.Bahna,
C.Ciatto,
G.Ahlsen,
B.Honig,
L.Shapiro,
and
A.G.Palmer
(2008).
Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins.
|
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Structure,
16,
1195-1205.
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A.Al-Amoudi,
D.C.Díez,
M.J.Betts,
and
A.S.Frangakis
(2007).
The molecular architecture of cadherins in native epidermal desmosomes.
|
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Nature,
450,
832-837.
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A.Kuhn,
and
H.Kunz
(2007).
Saccharide-induced peptide conformation in glycopeptides of the recognition region of LI-cadherin.
|
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Angew Chem Int Ed Engl,
46,
454-458.
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E.Parisini,
J.M.Higgins,
J.H.Liu,
M.B.Brenner,
and
J.H.Wang
(2007).
The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.
|
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J Mol Biol,
373,
401-411.
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PDB code:
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E.Pham,
J.Chiang,
I.Li,
W.Shum,
and
K.Truong
(2007).
A computational tool for designing FRET protein biosensors by rigid-body sampling of their conformational space.
|
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Structure,
15,
515-523.
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F.D'Amico,
and
E.Skarmoutsou
(2007).
Immunolocalization of E-cadherin and alphaE-catenin in rat parotid acinar cell under chronic stimulation of isoproterenol.
|
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Arch Oral Biol,
52,
161-167.
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H.Tsuiji,
L.Xu,
K.Schwartz,
and
B.M.Gumbiner
(2007).
Cadherin conformations associated with dimerization and adhesion.
|
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J Biol Chem,
282,
12871-12882.
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L.Shapiro,
J.Love,
and
D.R.Colman
(2007).
Adhesion molecules in the nervous system: structural insights into function and diversity.
|
| |
Annu Rev Neurosci,
30,
451-474.
|
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Q.T.Phan,
C.L.Myers,
Y.Fu,
D.C.Sheppard,
M.R.Yeaman,
W.H.Welch,
A.S.Ibrahim,
J.E.Edwards,
and
S.G.Filler
(2007).
Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells.
|
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PLoS Biol,
5,
e64.
|
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R.B.Troyanovsky,
O.Laur,
and
S.M.Troyanovsky
(2007).
Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion.
|
| |
Mol Biol Cell,
18,
4343-4352.
|
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S.Pokutta,
and
W.I.Weis
(2007).
Structure and mechanism of cadherins and catenins in cell-cell contacts.
|
| |
Annu Rev Cell Dev Biol,
23,
237-261.
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X.Chen,
C.Molino,
L.Liu,
and
B.M.Gumbiner
(2007).
Structural elements necessary for oligomerization, trafficking, and cell sorting function of paraxial protocadherin.
|
| |
J Biol Chem,
282,
32128-32137.
|
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Y.Huang,
Y.Zhou,
W.Yang,
R.Butters,
H.W.Lee,
S.Li,
A.Castiblanco,
E.M.Brown,
and
J.J.Yang
(2007).
Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.
|
| |
J Biol Chem,
282,
19000-19010.
|
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A.Batistatou,
A.K.Charalabopoulos,
C.D.Scopa,
Y.Nakanishi,
A.Kappas,
S.Hirohashi,
N.J.Agnantis,
and
K.Charalabopoulos
(2006).
Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma.
|
| |
Virchows Arch,
448,
763-767.
|
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A.K.Prakasam,
V.Maruthamuthu,
and
D.E.Leckband
(2006).
Similarities between heterophilic and homophilic cadherin adhesion.
|
| |
Proc Natl Acad Sci U S A,
103,
15434-15439.
|
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A.Prasad,
H.Zhao,
J.M.Rutherford,
N.Housley,
C.Nichols,
and
S.Pedigo
(2006).
Effect of linker segments on the stability of epithelial cadherin Domain 2.
|
| |
Proteins,
62,
111-121.
|
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D.Leckband,
and
A.Prakasam
(2006).
Mechanism and dynamics of cadherin adhesion.
|
| |
Annu Rev Biomed Eng,
8,
259-287.
|
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F.Cailliez,
and
R.Lavery
(2006).
Dynamics and stability of E-cadherin dimers.
|
| |
Biophys J,
91,
3964-3971.
|
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G.Suriano,
S.Seixas,
J.Rocha,
and
R.Seruca
(2006).
A model to infer the pathogenic significance of CDH1 germline missense variants.
|
| |
J Mol Med,
84,
1023-1031.
|
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H.Morishita,
M.Umitsu,
Y.Murata,
N.Shibata,
K.Udaka,
Y.Higuchi,
H.Akutsu,
T.Yamaguchi,
T.Yagi,
and
T.Ikegami
(2006).
Structure of the cadherin-related neuronal receptor/protocadherin-alpha first extracellular cadherin domain reveals diversity across cadherin families.
|
| |
J Biol Chem,
281,
33650-33663.
|
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H.P.Kiener,
D.M.Lee,
S.K.Agarwal,
and
M.B.Brenner
(2006).
Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.
|
| |
Am J Pathol,
168,
1486-1499.
|
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M.V.Bayas,
A.Leung,
E.Evans,
and
D.Leckband
(2006).
Lifetime measurements reveal kinetic differences between homophilic cadherin bonds.
|
| |
Biophys J,
90,
1385-1395.
|
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R.Z.Lin,
L.F.Chou,
C.C.Chien,
and
H.Y.Chang
(2006).
Dynamic analysis of hepatoma spheroid formation: roles of E-cadherin and beta1-integrin.
|
| |
Cell Tissue Res,
324,
411-422.
|
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S.D.Patel,
C.Ciatto,
C.P.Chen,
F.Bahna,
M.Rajebhosale,
N.Arkus,
I.Schieren,
T.M.Jessell,
B.Honig,
S.R.Price,
and
L.Shapiro
(2006).
Type II cadherin ectodomain structures: implications for classical cadherin specificity.
|
| |
Cell,
124,
1255-1268.
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PDB codes:
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Y.Yang,
H.Chen,
S.Wu,
Y.Yang,
X.Xu,
and
Y.Wu
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Citation data come partly from CiteXplore and partly
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only a partial list as not all journals are covered by
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so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
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