PDBsum entry 1e8k

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Isomerase PDB id
Protein chain
173 a.a. *
Waters ×229
* Residue conservation analysis

References listed in PDB file
Key reference
Title The first direct determination of a ligand binding constant in protein crystals.
Authors Wu sy, J.Dornan, G.Kontopidis, P.Taylor, M.D.Walkinshaw.
Ref. Angew Chem Int Ed Engl, 2001, 40, 582-586.
PubMed id 11180378
No abstract given.
Secondary reference #1
Title Biochemical and structural characterization of a divergent loop cyclophilin from caenorhabditis elegans.
Authors J.Dornan, A.P.Page, P.Taylor, S.Wu, A.D.Winter, H.Husi, M.D.Walkinshaw.
Ref. J Biol Chem, 1999, 274, 34877-34883. [DOI no: 10.1074/jbc.274.49.34877]
PubMed id 10574961
Full text Abstract
Figure 2.
Fig. 2. Molscript (51) overlay of the stuctures of C. elegans cyclophilin 3 and human cyclophilin A. The eight labeled strands are shown in purple, the two helices are shown in green, and ceCYP3 loop structure is shown in orange. The human CypA loop (in blue) contrasts with the shape adopted by the divergent loop, which is formed mainly by 7 additional residues (48KSGKPLH54) in the CYP-3 sequence.
Figure 3.
Fig. 3. Stereo diagram showing the active sites of CYP-3 and human cyclophilin A. This clearly shows the complete conservation of all 13 residues important in the binding of CsA, with the only significant structural difference between human CypA and CYP-3 being in the conformation adopted by Arg62 that places the side chain atoms 0.7Å apart.
The above figures are reproduced from the cited reference with permission from the ASBMB
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