|
|
||
|
|
|
|
|
UniProt functional annotation for Q07108 | ||
|
|
|
|
|
|
||
| UniProt code: Q07108. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. |
|
||
| Subunit: | |
Homodimer; disulfide-linked. {ECO:0000269|PubMed:11036086, ECO:0000269|PubMed:11101293, ECO:0000269|PubMed:18959746}. |
| Subcellular location: | |
Membrane; Single-pass type II membrane protein. |
| Tissue specificity: | |
Expressed on the surface of activated T-cells, B- cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. |
| Developmental stage: | |
Earliest inducible cell surface glycoprotein acquired during lymphoid activation. |
| Induction: | |
By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells. |
| Ptm: | |
Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes. |
Annotations taken from UniProtKB at the EBI.