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UniProt functional annotation for P56216 | ||
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| UniProt code: P56216. |
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| Organism: | |
Penicillium simplicissimum. |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium. |
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| Function: | |
Catalyzes the conversion of vanillin alcohol to vanillin, and also the conversion of a wide range of phenolic compounds bearing side chains of variable size at the para position of the aromatic ring. Crucial for the degradation of the secondary metabolites derived from the degradation of the lignin. Catalyzes besides the oxidation of 4- hydroxybenzyl alcohols, the oxidative deamination of 4- hydroxybenzylamines, the oxidative demethylation of 4-(methoxy- methyl)phenols and the oxidative hydration of 4-allylphenols. Most active with 4-allylphenols. |
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| Catalytic activity: | |
Reaction=4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin; Xref=Rhea:RHEA:10036, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18346, ChEBI:CHEBI:18353; EC=1.1.3.38; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD covalently per subunit.; |
| Activity regulation: | |
Competitively inhibited by cinnamyl and coniferyl alcohols and by isoeugenol. |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is about 10.; Temperature dependence: Optimum temperature is 38 degrees Celsius.; |
| Subunit: | |
Homooctamer (tetramer of tightly interacting dimers). |
| Subcellular location: | |
Peroxisome {ECO:0000269|PubMed:9475171}. Cytoplasm {ECO:0000269|PubMed:9475171}. |
| Induction: | |
By 4-methoxybenzyl alcohols, anisyl and veratryl alcohols. Repressed by carbon catabolite. |
| Similarity: | |
To bacterial flavocytochrome p-cresol methyl hydroxylase. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.