UniProt functional annotation for O75015



	UniProt functional annotation for O75015

UniProt code: O75015.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Subunit: Monomer. Interacts with INPP5D/SHIP1 (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.

Tissue specificity: Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.

Ptm: Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.

Ptm: The soluble form is produced by a proteolytic cleavage.

Polymorphism: There are three allelic forms of FCGR3B: FCGR3B*01 (NA- 1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides. {ECO:0000269|PubMed:15245367, ECO:0000269|PubMed:2521732, ECO:0000269|PubMed:2526846, ECO:0000269|PubMed:2967436, ECO:0000269|PubMed:7836402, ECO:0000269|PubMed:9028335}.

Miscellaneous: Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.


Subunit:		Monomer. Interacts with INPP5D/SHIP1 (By similarity). {ECO:0000250}.
Subcellular location:		Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.
Tissue specificity:		Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
Ptm:		Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
Ptm:		The soluble form is produced by a proteolytic cleavage.
Polymorphism:		There are three allelic forms of FCGR3B: FCGR3B01 (NA- 1), FCGR3B02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B01 and FCGR3B02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides. {ECO:0000269\|PubMed:15245367, ECO:0000269\|PubMed:2521732, ECO:0000269\|PubMed:2526846, ECO:0000269\|PubMed:2967436, ECO:0000269\|PubMed:7836402, ECO:0000269\|PubMed:9028335}.
Miscellaneous:		Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.