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UniProt functional annotation for P07306 | ||
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| UniProt code: P07306. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
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| Subunit: | |
Interacts with LASS2. {ECO:0000269|PubMed:11543633}. |
| Subunit: | |
(Microbial infection) Interacts with hepatitis E virus capsid protein ORF2. {ECO:0000269|PubMed:27155063}. |
| Subcellular location: | |
[Isoform H1a]: Membrane; Single-pass type II membrane protein. |
| Subcellular location: | |
[Isoform H1b]: Secreted {ECO:0000269|PubMed:20886072}. |
| Tissue specificity: | |
Expressed exclusively in hepatic parenchymal cells. |
| Ptm: | |
Phosphorylated on a cytoplasmic Ser residue. |
| Miscellaneous: | |
Calcium is required for ligand binding. |
Annotations taken from UniProtKB at the EBI.