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UniProt functional annotation for P00981 | ||
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| UniProt code: P00981. |
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| Organism: | |
Dendroaspis polylepis polylepis (Black mamba). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis. |
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| Function: | |
Serine protease inhibitor homolog that selectively blocks voltage-gated potassium channels homooligomer Kv1.1/KCNA1 (EC(50)=0.6 nM) and Kv1.1-containing heterooligomer. {ECO:0000269|PubMed:10429207, ECO:0000269|PubMed:8612784, ECO:0000269|PubMed:9134213}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Toxic dose: | |
LD(50) is 30 mg/kg by intravenous injection. |
| Miscellaneous: | |
Does not inhibit serine proteases and voltage-gated potassium channels Kv1.2/KCNA2 and Kv1.6/KCNA6. {ECO:0000305|PubMed:8612784}. |
| Similarity: | |
Belongs to the venom Kunitz-type family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.