UniProt functional annotation for Q9XHH2



	UniProt functional annotation for Q9XHH2

UniProt code: Q9XHH2.

Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii).

Taxonomy: Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae; CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.

Function: Part of the multisubunit axonemal ATPase complexes that generate the force for flagellar motility and govern beat frequency (PubMed:19620633). Component of the outer arm dynein (ODA) (PubMed:19620633). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (ODA2) to the A- tubule of the outer doublet microtubules within the axoneme (PubMed:22157010, PubMed:10353837, PubMed:19620633). {ECO:0000269|PubMed:10353837, ECO:0000269|PubMed:19620633, ECO:0000269|PubMed:22157010}.

Subunit: Interacts with OCAD2, a outer arm dynein heavy chain (PubMed:19620633, PubMed:22157010). Interacts with tubulin (previously called p45) located within the A-tubule of the outer doublets in a ATP- independent manner (PubMed:19620633, PubMed:10876244, PubMed:22157010). {ECO:0000269|PubMed:10876244, ECO:0000269|PubMed:19620633, ECO:0000269|PubMed:22157010}.

Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:19620633}.

Miscellaneous: Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms. {ECO:0000303|PubMed:19620633}.

Similarity: Belongs to the dynein light chain LC1-type family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Chlamydomonas reinhardtii (Chlamydomonas smithii).
Taxonomy:		Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae; CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.



Function:		Part of the multisubunit axonemal ATPase complexes that generate the force for flagellar motility and govern beat frequency (PubMed:19620633). Component of the outer arm dynein (ODA) (PubMed:19620633). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (ODA2) to the A- tubule of the outer doublet microtubules within the axoneme (PubMed:22157010, PubMed:10353837, PubMed:19620633). {ECO:0000269\|PubMed:10353837, ECO:0000269\|PubMed:19620633, ECO:0000269\|PubMed:22157010}.


Subunit:		Interacts with OCAD2, a outer arm dynein heavy chain (PubMed:19620633, PubMed:22157010). Interacts with tubulin (previously called p45) located within the A-tubule of the outer doublets in a ATP- independent manner (PubMed:19620633, PubMed:10876244, PubMed:22157010). {ECO:0000269\|PubMed:10876244, ECO:0000269\|PubMed:19620633, ECO:0000269\|PubMed:22157010}.
Subcellular location:		Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269\|PubMed:19620633}.
Miscellaneous:		Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms. {ECO:0000303\|PubMed:19620633}.
Similarity:		Belongs to the dynein light chain LC1-type family. {ECO:0000305}.