UniProt functional annotation for P33681



	UniProt functional annotation for P33681

UniProt code: P33681.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269|PubMed:10583602}.

Function: (Microbial infection) Acts as a receptor for adenovirus subgroup B. {ECO:0000269|PubMed:16920215}.

Subunit: Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement. {ECO:0000269|PubMed:10583602, ECO:0000269|PubMed:11279502}.

Subunit: (Microbial infection) Interacts with adenovirus subgroup B fiber proteins. {ECO:0000269|PubMed:16920215}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells.

Miscellaneous: [Isoform 2]: Soluble isoform. Expressed in unstimulated B-cells and monocytes, but not T-cells. {ECO:0000305}.

Miscellaneous: [Isoform 3]: Soluble isoform. Expressed in T-cells activated by ConA, non-activated monocytes and monocytes activated with IFN-c. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269\|PubMed:10583602}.



Function:		(Microbial infection) Acts as a receptor for adenovirus subgroup B. {ECO:0000269\|PubMed:16920215}.


Subunit:		Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement. {ECO:0000269\|PubMed:10583602, ECO:0000269\|PubMed:11279502}.
Subunit:		(Microbial infection) Interacts with adenovirus subgroup B fiber proteins. {ECO:0000269\|PubMed:16920215}.
Subcellular location:		Membrane; Single-pass type I membrane protein.
Tissue specificity:		Expressed on activated B-cells, macrophages and dendritic cells.
Miscellaneous:		[Isoform 2]: Soluble isoform. Expressed in unstimulated B-cells and monocytes, but not T-cells. {ECO:0000305}.
Miscellaneous:		[Isoform 3]: Soluble isoform. Expressed in T-cells activated by ConA, non-activated monocytes and monocytes activated with IFN-c. {ECO:0000305}.