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UniProt functional annotation for P10226 | ||
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| UniProt code: P10226. |
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| Organism: | |
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus. |
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| Function: | |
Plays an essential role in viral DNA replication by acting as the polymerase accessory subunit. Associates with the viral polymerase to increase its processivity and forms high-affinity direct interactions with DNA. Facilitates the origin-binding protein UL9 loading onto DNA thus increasing its ability to assemble into a functional complex capable of unwinding duplex DNA. {ECO:0000269|PubMed:2173776}. |
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| Subunit: | |
Interacts with the DNA polymerase catalytic subunit UL30. Interacts with the origin-binding protein. {ECO:0000269|PubMed:15673714, ECO:0000269|PubMed:2173776}. |
| Subcellular location: | |
Host nucleus. |
| Similarity: | |
Belongs to the herpesviridae DNA polymerase processivity factor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.